Перегляд за автором "Rynditch, A.V."

Сортувати за: Порядок: Результатів:

  • Alternatively spliced short and long isoforms of adaptor protein intersectin 1 form complexes in mammalian cells 
    Gubar, O.S.; Kropyvko, S.V.; Tsyba, L.O.; Gasman, S.; Rynditch, A.V. (Вiopolymers and Cell, 2012)
    Intersectin 1 (ITSN1) is an adaptor protein involved in membrane trafficking and cell signaling. Long and short isoforms of ITSN1 (ITSN1-L and ITSN1-S) are produced by alternative splicing. The aim of our study was ...
  • Amphiphysin 1 and 2 interact with latent membrane protein 2A of Epstein-Barr virus and regulate its exosomal secretion 
    Dergai, O.V.; Dergai, M.V.; Tsyba, L.O.; Yaruchik, A.M.; Rynditch, A.V.; Skrypkina, I.Ya. (Вiopolymers and Cell, 2012)
    Латентный мембранный белок 2А вируса Эпштейна-Барр является ключевым регулятором латентной фазы вирусной инфек- ции. Цель. Идентифицировать белки, способные связываться с пролин-обогащенными мотивами LMP2A. Методы. Анализ ...
  • Ca²⁺ does not affect the binding properties of ITSN1 EH domains 
    Morderer, D.Ye.; Rymarenko, O.V.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2014)
    ITSN1 is an endocytic scaffold protein implicated in synaptic functioning. Ca²⁺ is known to be important for endo- cytosis in both pre- and post-synaptic terminals. ITSN1 contains two EH (Eps15 homology) domains which ...
  • Ca/calmodulin-dependent phosphorylation of endocytic scaffold ITSN1 
    Morderer, D.Ye.; Nikolaienko, O.V.; Skrypkina, I.Ya.; Rymarenko, O.V.; Kropyvko, S.V.; Tsyba, L.O.; Rynditch, A.V. (Вiopolymers and Cell, 2014)
    ITSN1 is an endocytic scaffold protein with a prominent function in synaptic transmission. It is known that Ca signaling is crucial for the regulation of synaptic proteins functioning. Aim. Checking the possibility of ...
  • Comparative analysis of epigenetic markers in plasma and tissue of patients with colorectal cancer 
    Kondratov, A.G.; Nekrasov, K.A.; Lototska, L.V.; Panasenko, G.V.; Stoliar, L.A.; Lapska, Y.V.; Kolesnyk, O.O.; Shchepotin, I.B.; Rynditch, A.V.; Kashuba, V.I. (Вiopolymers and Cell, 2014)
    Aim. The work is devoted to the development of less invasive tools for the colorectal cancer (CRC) screening. Methods. Q-PCR and methylation-specific PCR techniques were used in the current work. Results. We have shown ...
  • Development of gene expression panels to determine prostate cancer 
    Gerashchenko, G.V.; Rynditch, A.V.; Kashuba, V.I. (Доповіді НАН України, 2019)
    The aim of this investigation is to prove a modified algorithm for statistical approaches to develop gene expression panels for the detection of prostate tumors. According to Classification and Regression tree models and ...
  • Differential recognition of ITSN2/Ese2 by the SH2 domains of Fyn, Abl1, PLCg1 and PI3KR1 in mouse tissues 
    Novokhatska, O.V.; Pankivskyy, S.V.; Dergai, M.V.; Tsyba, L.O.; Rynditch, A.V. (Вiopolymers and Cell, 2013)
    Phosphorylation of endocytic adaptor ITSN2 that enabled its interaction with the SH2 domains of signaling proteins was recently reported. The aim of this study was to determine whether tissue-specific ITSN2 phosphorylation ...
  • Distribution and expression of chicken endogenous retroviruses in the host genome 
    Borisenko, L.G.; Rynditch, A.V.; Bernardi, G. (Біополімери і клітина, 2004)
    The distribution of seven groups of endogenous retroviruses (ALV-related ev loci, HERV-I-related proviruses, EAV-HP, EAV-0, E-33, E-51, ART-CH) in the genome of domestic chicken (Gallus gallus) was studied according to the ...
  • Expression of ITSN2 and TKS5 in different subtypes of breast cancer tumors 
    Kropyvko, S.V.; Tsyba, L.O.; Novokhatska, O.V.; Nemesh, Y.M.; Syvak, L.A.; Tarasenko, T.Ye.; Grabovoy, A.N.; Rynditch, A.V. (Вiopolymers and Cell, 2019)
    Aim. Regardless a great progress in treatment, 15% of breast cancer cases remain lethal. One of the main problems in diagnosis and cure of this cancer type is its high clinical and genetic heterogeneity, and the identification ...
  • Focal adhesion kinase (FAK1) regulates SHB phosphorylation and its binding with a range of signaling proteins 
    Dergai, O.V.; Yaruchik, A.M.; Rynditch, A.V. (Вiopolymers and Cell, 2016)
    Aim. To investigate an effect of the Focal adhesion kinase 1 (FAK1) expression on the level of tyrosine phosphorylation of an adaptor protein SHB and to find functional consequences of this posttranslational modification. ...
  • Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas 
    Gerashchenko, G.V.; Bogatyrova, O.O.; Rudenko, E.E.; Kondratov, A.G.; Gordiyuk, V.V.; Zgonnyk, Y.M.; Vozianov, O.F.; Pavlova, T.V.; Zabarovsky, E.R.; Rynditch, A.V.; Kashuba, V.I. (Experimental Oncology, 2010)
    Renal cell carcinoma (RCC) is the most common malignant tumor of kidney associated with the worst clinical outcome. No molecular markers for RCC diagnostics and prognosis that could be applied in clinics were described ...
  • Identification and functional analysis of an alternative promoter of human intersectin 1 gene 
    Kropyvko, S.V.; Tsyba, L.O.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2010)
    Intersectin 1 (ITSN1) gene encodes an evolutionarily conserved adaptor protein that functions in clathrin-mediated endocytosis, cell signalling, apoptosis and cytoskeleton rearrangements. Its expression is characterized ...
  • Identification of Ca²⁺/calmodulin-dependent phosphorylation sites of endocytic scaffold ITSN1 by tandem mass spectrometry 
    Morderer, D.Ye.; Nikolaienko, O.V.; Rynditch, A.V. (Вiopolymers and Cell, 2015)
    ITSN1 is a scaffold protein involved in endocytosis, signal transduction and cytoskeleton regulation. It has been previously shown that ITSN1 undergoes Ca²⁺/calmodulin-dependent phosphorylation in vitro. Aim. We intend to ...
  • Interaction between adaptor proteins Ruk/CIN85 and Tks4 in normal and tumor cells of different tissue origins 
    Bazalii, A.V.; Samoylenko, A.A.; Petukhov, D.M.; Rynditch, A.V.; Redowicz, M.-J.; Drobot, L.B. (Вiopolymers and Cell, 2014)
    Aim. To study the interaction of adaptor protein Ruk/CIN85 SH3 domains with endogenous adaptor protein Tks4 in normal and tumor cells of different tissue origins. Methods. GST in vitro pull-down assay was performed using ...
  • Interaction of ubiquitin ligase CBL with LMP2A protein of Epstein-Barr virus occurs via PTB domain of CBL and does not depend on adaptor ITSN1 
    Dergai, O.V.; Dergai, M.V.; Gudkova, D.O.; Tsyba, L.O.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2013)
    Aim. Previously Latent membrane protein 2A (LMP2A) of Epstein-Barr virus was found to be ubiquitylated by CBL ubiquitin ligase but no direct interaction of LMP2A with CBL was reported. We aimed to explore this interaction ...
  • ITSN1 and Ruk/CIN85 colocalized to clathrin-coated pits in MCF-7 cells 
    Nikolaienko, O.V.; Skrypkina, I.Ya.; Tsyba, L.O.; Drobot, L.B.; Rynditch, A.V. (Вiopolymers and Cell, 2009)
    Activation of receptor tyrosine kinases (RTK) by corresponding ligands results not only in signal propagation, but also initiates a number of processes, such as clathrin-mediated endocytosis, which precisely regulate ...
  • ITSN protein family: regulation of diversity, role in signalling and pathology 
    Tsyba, L.O.; Dergai, M.V.; Skrypkina, I.Ya.; Nikolaienko, O.V.; Dergai, O.V.; Kropyvko, S.V.; Novokhatska, O.V.; Morderer, D.Ye.; Gryaznova, T.A.; Gubar, O.S.; Rynditch, A.V. (Вiopolymers and Cell, 2013)
    Adaptor/scaffold proteins of the intersectin (ITSN) family are important components of endocytic and signalling complexes. They coordinate trafficking events with actin cytoskeleton rearrangements and modulate the activity ...
  • Novel isoform of adaptor protein ITSN1 forms homodimers via its C-terminus 
    Dergai, M.V.; Dergai, O.V.; Tsyba, L.O.; Novokhatska, O.V.; Skrypkina, I.Ya.; Rynditch, A.V. (Вiopolymers and Cell, 2011)
    Aim. Previously we have identified a novel isoform of endocytic adaptor protein ITSN1 designated as ITSN1- 22a. Western blot revealed two immunoreactive bands of 120 and 250 kDa that corresponded to ITSN1-22a. The goal ...
  • RNA-binding protein SAM68 interacts with endocytic proteins and actin cyto skeleton modulators 
    Pankivskyi, S.V.; Senchenko, N.V.; Busko, P.B.; Rynditch, A.V. (Доповіді НАН України, 2020)
    SAM68 is a nuclear RNA-binding protein involved in the regulation of mRNA processing. SAM68 overexpression is observed in multiple types of cancer. Recently, the possible link between RNA-binding protein SAM68 and ...
  • RTK signaling regulator SPRY2 associates with endocytic adaptor ITSN1 in vivo 
    Novokhatska, O.V.; Skrypkina, I.Ya.; Dergai, M.V.; Tsyba, L.O.; Rynditch, A.V. (Вiopolymers and Cell, 2012)
    Передача митогенного сигнала от RTK (рецепторных тирозиновых киназ) тесно связана с эндоцитозом, регулирующим ее точность. Интерсектин 1 (ITSN1) – эволюционно-консервативный адапторный белок, вовлеченный в самые ранние ...